If your are using the excellent Emacs for Mac OS X distribution, you may have noticed that it does not use the environment you may have defined in your ~/.bashrc. This can be a problem if you are using MacPorts, for example to install clojure and Leiningen. You will get an error message like this, when trying to run inferior-lisp in clojure-mode:
apply: Searching for program: No such file or directory, lein
This can be avoided by using the excellent exec-path-from-shell package for Emacs. It is available via (M)ELPA, just install it using list-packages, or download it from github. You can enable it, especially for OS X, by putting this in your init.el:
(when (memq window-system '(mac ns))
(exec-path-from-shell-initialize))